Patents
Patents related to talassemia:
Title: Synthetic oligonucleotides as inducers of erythroid differentiation
Description: This patent is related to a property of a double stranded synthetic oligonucleotide to induce erythroid differentiation, accumulation of fetal hemoglobin (HbF) and gamma-globin gene expression. We have demonstrated that this oligonucleotide binds nuclear factors and induces erythroid differentiation and increases HbF production in primary human erythroid precursor cells.
Compared to the traditional treatment of beta-thalassemia the use of the indicated molecules has the following specific advantages: (a) in respect to gene-therapy, is simple and far less expensive; (b) it is expected to be specific.
Inventors: Bianchi N, Feriotto G, Gambari R, Mischiati C.
Property: Università degli Studi di Ferrara; Associazione Veneta per la Lotta alla Talassemia; Associazione per la Lotta alla Talassemia di Ferrara.
Title: Use of heterocyclic and benzoheterocyclic polyamides structurally related to the natural antibiotic distamycin A for the treatment of beta-thalassaemia
Description: The invention relates to the use of structural analogues of distamycin having the general formula (I), (II), (III), (IV) or (V) or their pharmaceutically acceptable salts, for the preparation of a medicament for the therapeutic treatment of beta-thalassaemia.
Inventors: Baraldi PG, Bianchi N, Feriotto G, Gambari R,Mischiati C, Romagnoli R.
Property: Associazione per la lotta alla Talassemia di Ferrara; Associazione Veneta per la lotta alla talassemia di Rovigo; Università degli Studi di Ferrara.
Title: A novel use of rapamycin and structural analogues thereof
Description: This patent is related to a property of a drug (RAPAMYCIN) used in kidney transplantation to induce erythroid differentiation, accumulation of fetal hemoglobin (HbF) and gamma-globin gene expression. Rapamycin is a lipophilic macrolide also called sirolimus, isolated from a strain of Streptomyces hygroscopicus found in a soil from Easter Island (known by the inhabitants as Rapa Nui). Specifically, rapamycin and related compounds are of great interest because: (a) rapamycin (as Sirolimus or Rapamune) has been approved by the U.S. Food and Drug Administration for prevention of acute rejection in renal transplant recipients; (b) limited toxicity assays will be required.
Inventors: Bianchi N, Borgatti M, Gambari R, Mischiati C.
Property: Università degli Studi di Ferrara; Associazione Veneta per la Lotta alla Talassemia.
Title: A novel use of angelicin and structural analogues for therapy of thalassemia
Description: This patent is related to a property of angelicin (a drug used for PUVA therapy of psoriasis, together with 5-MOP and 8-MOP) to induce erythroid differentiation, accumulation of fetal hemoglobin (HbF) and gamma-globin gene expression. Angelicin belongs to furocoumarins and related compounds. Specifically, angelicin and related compounds are of great interest because: (a) analogues of angelicin (5-MOP) has been approved by the U.S. Food and Drug Administration for treatment of psoriasis; (b) limited toxicity assays will be required.
Inventors: Bianchi N, Borgatti M, Gambari R, Lampronti I.
Property: Università degli Studi di Ferrara; Associazione Veneta per la Lotta alla Talassemia
Title: Double-stranded synthetic oligonucleotides useful for inducing apoptosis of osteoclasts for the treatment of ostopenic pathologies
Description: Use of decoy oligonucletides mimicking estrogen receptor promoter in order to induce apoptosis in human osteoclasts as therapeutic treatment of osteopenic diseases, including osteoporosis, rheumatoid arthritis and bone metastases associated with some cancers, like breast cancer, myeloma and osteosarcoma.
Inventors: Gambari R, Penolazzi L, Piva R.
Property: Associazione Veneta per la lotta alla Talassemia di Rovigo; Università degli Studi di Ferrara.
Title: Drug for treating thalassemia, falciform anemia and all other forms of anemia treatable therewith
Description: The use of UVA treatment and psoralens to induce erythroid differentiation and fetal hemoglobin production as therapeutic treatment of thalassemia.
Inventors: Bianchi N, Borgatti M, Gambari R, Lampronti I, Dall'Acqua F, Vevaldi D, Viola G.
Property: Università degli Studi di Ferrara; Università degli Studi di Padova; Associazione Veneta per la lotta alla Talassemia.
Title: Everolimus quale induttore di mRNA per la globina gamma nel trattamento della beta talassemia
Everolimus as inducer of mRNA gamma-globin for the treatment of beta-thalassemia.
Description: The use of Everolimus to induce erythroid differentiation and fetal hemoglobin production as therapeutic treatment of thalassemia.
Inventors: Bianchi N, Borgatti M, Gambari R, Lampronti I.
Property: Gambari Roberto; Associazione Veneta per la lotta alla Talassemia.
Patents related to other pathologies:
Title: Effetto anti-infiammatorio di trimetil-angelicina su cellule dell’epitelio bronchiale
Description: Use of trimetilangelicin and its structural analogues as potent inhibitors of IL-8 mRNA production in cystic fibrosis cells infected with Pseudomonas aeruginosa. This molecule is proposed for anti-inflammatory therapy of cystic fibrosis.
Inventors: Tamanini A, Borgatti M, Dechecchi MC, Lampronti I, Nicolis E, Mancini I, Bezzerri V, Rizzotti P, Cabrini G, Gambari R.
Property: Azienda Ospedaliera "Istituti Ospitaleri di Verona", Università degli Studi di Ferrara, Fondazione Italiana per la Ricerca sulla Fibrosi Cistica, Ospedale Civile Maggiore.
Title: Effetto anti-infiammatorio del miglustat su cellule dell’epitelio bronchiale.
Description: Use of miglustat as a potent inhibitor of IL-8 mRNA production in cystic fibrosis cells infected with Pseudomonas aeruginosa. This molecule is proposed for anti-inflammatory therapy of cystic fibrosis.
Inventors: Dechecchi MC, Borgatti M, Tamanini A, Lampronti I, Nicolis E, Mancini I, Bezzerri V, Mazzi P, Rizzotti P, Berton G, Gambari R, Cabrini G.
Property: Azienda Ospedaliera "Istituti Ospitaleri di Verona", Università degli Studi di Ferrara, Università degli Studi di Verona, Fondazione Italiana per la Ricerca sulla Fibrosi Cistica- Ospedale
Civile Maggiore.
Title: Diagnostic and therapeutic application of CTL and NK cells functionally selected.
Description: A new diagnostic and therapeutic methods based on the use of effector cells (such as CTL and NK cells) selected to be able to induce lysis in target cells. In particular it is possible the selection of effector cells according to their lytic activity in ordet to improve well-known cellular therapies.
Inventors: Gambari Roberto, Guerrieri Roberto.
Property: Gambari Roberto; Silicon Biosystem.
Patents related to diagnosis:
Title: Valore diagnostico del rilascio di molecole HLA-G solubili da parte di oociti umani maturati in vitro.
Description: The following patent is related to the issue of in vitro fertilization and embryo transfer with the aim to detect the best oocytes to be employed in the procedure. In fact, successful embryo formation and implantation are critical steps during in vitro fertilization procedure. We have demonstrated that the release by human oocytes of HLA-G is predictive of maturation and it will be used as marker for selection of the most promising oocytes cultured in vitro obtained by in vitro fertilization.
Inventors: Baricordi O, Borgatti M, Dal Canto B, Fadini R, Gambari R, Rizzo R.
Property: Gambari R, Baricordi O.
Title: Valore diagnostico del rilascio di ICAM-1 da parte di embrioni umani in coltura.
Description: The following patent is related to the issue of in vitro fertilization and embryo transfer with the aim to detect the best embryos to be employed in the procedure. In fact, successful embryo formation and implantation are critical steps during in vitro fertilization procedure. We have demonstrated that the release by human embryos of ICAM-1 (Intercellular Adhesion Molecule 1) is predictive of maturation and it will be used as marker for the selection of the most promising embryos obtained by in vitro fertilization.
Inventors: Baricordi O, Borgatti M, Gambari R, Rizzo R
Property: Gambari R, Baricordi OR
