Laboratory for the development of Genetic and Pharmacogenomic Therapy of Thalassemia

Director:
Prof. Roberto Gambari
E-mail: gam@unife.it

Responsible External Relations/Research & Development
Dr. Michele Lipucci Di Paola
E-mail: mlipucci@unipi.it

Editorial

ThalLab: past, present and future

(Release 1, September, 2009)

Roberto Gambari
Full Professor of Biochemistry (BIO/10)
Ferrara University,
Director of ThalLab

The aim of this commentary article is to present the results obtained by the ThalLab during the past few years; recently several research project have been completed and relative publications submitted and accepted by important international journals (Blood, J Biol Chem, J Med Chem, Eur J Hematol, Am J Hematol, Apoptosis). Several milestones have been reached and novel fields of investigation have been added to the main topics of ThalLab. Some of these novel research areas should be in the future object of great efforts by the researchers at ThalLab.

At present, ThalLab is constituted by a scientific group composed by more than 12 researchers (mainly PhD students and research fellows). The most important external collaborators of ThalLab are Prof. Stefano Rivella (Cornell University, New York) and Prof. Eitan Fibach (Hadassah Hospital, Jerusalem, Israel). The scientific activity of at ThalLab is funded, at it will be described, by Telethon, by Foundation Cassa di Risparmio di Padova e Rovigo and by Veneta Association for the Fight against Thalassemia, AVLT.

The Laboratory

The Laboratory has been activated following an Agreement of collaboration between the Center of Biotechnology of University of Ferrara (CBF), Via Fossato di Mortara n. 64/B and the Veneta Association for the Fight against Thalassemia (AVTL) of Rovigo.

The Biotechnology Center, Ferrara University

The LABORATORY FOR THE DEVELOPMENT OF GENETIC AND PHARMACOGENOMIC THERAPY OF THALASSEMIA is located within the Biotechnology Center of Ferrara University (CBF). This is a partial list of the relevent equipments located at the

Specific objectives of the laboratory

The objectives of the ThalLab are the following:

1. The identification of new inducers of erythroid differentiation of K562 cells.

2. The development of new technologies for isolation, cloning and in vitro induction of hematopoietic cells. A first objective was to transfer at the University of Ferrara the method developed by Eitan Fibach (Blood, 73, 100-103, 1989) on erythroid progenitors from peripheral blood. This method was very important for complete the research carried out on K562 cells, allowing the identification of HbF inducers.

3. The development of RT-PCR approaches for the identification of inducers of gamma-globini gene expression.

4. The development of patents on molecules able to induce erythroid differentiation. The objective of the period 2000-2002 was to produce three new patents.

5. To perform experiments on the issue of synthetic oligonucleotides able to induce erythroid differentiation.

6. To publish research papers and reviewes on international journals on Thalassemia, citing the sponsorship of the Veneta Association.

7. The organization of seminars and workshops on international research activities concerning haematological diseases.

8. The production of tools (WEB sites, CD-rom) for the dissemination of the knowledge of the molecular bases and the therapy of beta-talassemia.

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Collaboration with:

Laboratory for the development of Genetic and Pharmacogenomic Therapy of Thalassemia

Editorial

ThalLab: past, present and future

The Laboratory

The Biotechnology Center, Ferrara University

Specific objectives of the laboratory

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