Laboratorio di ricerca sulla terapia genica e farmacogenomica della Talassemia

1)    Salvatori F, Cantale V, Breveglieri G, Zuccato C, Finotti A, Bianchi N, Borgatti M, Feriotto G, Destro F, Canella A, Breda L, Rivella S, Gambari R. Development of K562 cell clones expressing beta-globin mRNA carrying the beta039 thalassemia mutation for the screening of correctors of stop codon mutations. Biotechnol Appl Biochem. 2009 Feb 13

2)    Landi M, Catelani G, D'Andrea F, Ghidini E, Amari G, Paola P, Bianchi N, Gambari R. Synthesis of glycose carbamides and evaluation of the induction of erythroid differentiation of human erythroleukemic K562 cells. Eur J Med Chem. 2009 Feb;44(2):745-54

3)     Bianchi N, Borgatti M, Fibach E, Prus E, Zuccato C, Breveglieri G, Baraldi PG, Romagnoli R, Gambari R. Bis-epoxyethyl derivatives of distamycin A modified on the amidino moiety: induction of production of fetal hemoglobin in human erythroid precursor cells. Int J Mol Med. 2009 Jan;23(1):105-11

4)    Accetta A, Corradini R, Sforza S, Tedeschi T, Brognara E, Borgatti M, Gambari R, Marchelli R. New uracil dimers showing erythroid differentiation inducing activities. J Med Chem. 2009 Jan 8;52(1):87-94

5)    Viola G, Vedaldi D, Dall'Acqua F, Lampronti I, Bianchi N, Zuccato C, Borgatti M, Gambari R. Furocoumarins photolysis products induce differentiation of human erythroid cells. J Photochem Photobiol B. 2008 Jul 24;92(1):24-8

6)    Feriotto G, Salvatori F, Finotti A, Breveglieri G, Venturi M, Zuccato C, Bianchi N, Borgatti M, Lampronti I, Mancini I, Massei F, Favre C, Gambari R. A novel frameshift mutation (+A) at codon 18 of the beta-globin gene associated with high persistence of fetal hemoglobin phenotype and deltabeta-thalassemia. Acta Haematol. 2008;119(1):28-37

7)    Viola G, Vedaldi D, Dall'Acqua F, Fortunato E, Basso G, Bianchi N, Zuccato C, Borgatti M, Lampronti I, Gambari R. Induction of gamma-globin mRNA, erythroid differentiation and apoptosis in UVA-irradiated human erythroid cells in the presence of furocumarin derivatives. Biochem Pharmacol. 2008 Feb 15;75(4):810-25

8)    Bianchi N, Zuccato C, Lampronti I, Borgatti M, Gambari R. Fetal Hemoglobin Inducers from the Natural World: a novel approach for identification of drugs for the treatment of -Thalassemia and Sickle-Cell Anemia. Evid Based Complement Alternat Med. 2007 Dec 11

9)     Gambari R, Fibach E. Medicinal chemistry of fetal hemoglobin inducers for treatment of beta-thalassemia. Curr Med Chem. 2007;14(2):199-212

10)     Zuccato C, Bianchi N, Borgatti M, Lampronti I, Massei F, Favre C, Gambari R. Everolimus is a potent inducer of erythroid differentiation and gamma-globin gene expression in human erythroid cells. Acta Haematol. 2007;117(3):168-76

11)     Fibach E, Bianchi N, Borgatti M, Zuccato C, Finotti A, Lampronti I, Prus E, Mischiati C, Gambari R. Effects of rapamycin on accumulation of alpha-, beta- and gamma-globin mRNAs in erythroid precursor cells from beta-thalassaemia patients. Eur J Haematol. 2006 Nov;77(5):437-41
 
12)     Lampronti I, Bianchi N, Zuccato C, Medici A, Bergamini P, Gambari R. Effects on erythroid differentiation of platinum(II) complexes of synthetic bile acid derivatives. Bioorg Med Chem. 2006 Aug 1;14(15):5204-10

13)     Mischiati C, Sereni A, Lampronti I, Bianchi N, Borgatti M, Prus E, Fibach E, Gambari R. Rapamycin-mediated induction of gamma-globin mRNA accumulation in human erythroid cells. Br J Haematol. 2004 Aug;126(4):612-21

14)     Lampronti I, Bianchi N, Borgatti M, Fibach E, Prus E, Gambari R. Accumulation of gamma-globin mRNA in human erythroid cells treated with angelicin. Eur J Haematol. 2003 Sep;71(3):189-95

15)     Chiarabelli C, Bianchi N, Borgatti M, Prus E, Fibach E, Gambari R. Induction of gamma-globin gene expression by tallimustine analogs in human erythroid cells. Haematologica. 2003 Jul;88(7):826-7

16)     Fibach E, Bianchi N, Borgatti M, Prus E, Gambari R. Mithramycin induces fetal hemoglobin production in normal and thalassemic human erythroid precursor cells. Blood. 2003 Aug 15;102(4):1276-81

17)     Catelani G, D'Andrea F, Mastrorilli E, Bianchi N, Chiarabelli C, Borgatti M, Martello D, Gambari R. Preparation and evaluation of the in vitro erythroid differentiation induction properties of some esters of methyl 3,4-O-isopropylidene-beta-D-galactopyranoside and 2,3-O-isopropylidene-D-mannofuranose. Bioorg Med Chem. 2002 Feb;10(2):347-53

18)     Bianchi N, Chiarabelli C, Borgatti M, Mischiati C, Fibach E, Gambari R. Accumulation of gamma-globin mRNA and induction of erythroid differentiation after treatment of human leukaemic K562 cells with tallimustine. Br J Haematol. 2001 Jun;113(4):951-61

19)     Bianchi N, Ongaro F, Chiarabelli C, Gualandi L, Mischiati C, Bergamini P, Gambari R. Induction of erythroid differentiation of human K562 cells by cisplatin analogs. Biochem Pharmacol. 2000 Jul 1;60(1):31-40

20)     Catelani G, Osti F, Bianchi N, Bergonzi MC, D'Andrea F, Gambari R. Induction of erythroid differentiation of human K562 cells by 3-O-acyl-1,2-O-isopropylidene-D-glucofuranose derivatives. Bioorg Med Chem Lett. 1999 Nov 1;9(21):3153-8

21)     Bianchi N, Osti F, Rutigliano C, Corradini FG, Borsetti E, Tomassetti M, Mischiati C, Feriotto G, Gambari R. The DNA-binding drugs mithramycin and chromomycin are powerful inducers of erythroid differentiation of human K562 cells. British J. Haematol., 1999, 104:258-65

22)     Cortesi R, Gui V, Osti F, Nastruzzi C, Gambari R. Human leukemic K562 cells treated with cytosine arabinoside: enhancement of erythroid differentiation by retinoic acid and retinol. Eur. J. Haematol. 1998, 61(5):295-30

23)     Osti F, Corradini FG, Hanau S, Matteuzzi M, Gambari R. Human leukemia K562 cells: induction to erythroid differentiation by guanine, guanosine and guanine nucleotides. Haematologica 1997, 82(4):395-401

24)     Bianchi Scarrà G, Fiorentini P, Gambari R, Nastruzzi C, Barbieri R, Sessarego M, Ravazzolo R, Garre C. Isolation and characterization of a K562 cell line resistant to 1-beta-D-arabinofuranosylcytosine-mediated erythroid induction. Exp Hematol 1989, 17(8):859-64

25)     Feriotto G, Nastruzzi C, Barbieri R, Gambari R. Induction to erythroid differentiation of K562 cells by 1-beta-D-arabinofuranosylcytosine is inhibited by iron chelators: reversion by treatment with hemin. Blut 1988, 57(1):25-30

26)     Viola L, Biagini R, Barbieri R, Gambari R. Inhibition of hemoglobin accumulation by monoclonal antibodies to the human transferrin receptor is reversed by hemin. Exp Hematol 1987, 15(11):1145-52

27)     Gambari R, Barbieri R, Buzzoni D, Bernardi F, Marchetti G, Amelotti F, Piva R, Viola L, del Senno L. Human leukemic K562 cells: suppression of hemoglobin accumulation by a monoclonal antibody to human transferrin receptor. Biochim Biophys Acta 1986, 886(2):203-13

28)     Gambari R, Amelotti F, Piva R. Efficient cell proliferation and predominant accumulation of epsilon-globin mRNA in human leukemic K562 cells which produce mostly Hb Gower 1. Experientia 1985, 41(5):673-5

29)     Gambari R, del Senno L, Piva R, Barbieri R, Amelotti F, Bernardi F, Marchetti G, Citarella F, Tripodi M, Fantoni A. Human leukemia K562 cells: relationship between hemin-mediated erythroid induction, cell proliferation and expression of c-abl and c-myc oncogenes. Biochem Biophys Res Commun 1984, 125(1):90-6

30)     Farace MG, Hill A, Tripodi M, Padgett RW, Raschella G, Gambari R, Fantoni A, Hutchison CA 3d, Edgell MH. Molecular cloning and sequence analysis of a cDNA coding for the mouse alpha-like embryonic globin chain x. Gene 1984, 31(1-3):241-5

31)     Farace MG, Brown BA, Raschella G, Alexander J, Gambari R, Fantoni A, Hardies SC, Hutchison CA 3d, Edgell MH. The mouse beta h1 gene codes for the z chain of embryonic hemoglobin. J Biol Chem 1984, 259(11):7123-8

32)     Gambari R, del Senno L, Barbieri R, Viola L, Tripodi M, Raschella G, Fantoni A. Human leukemia K-562 cells: induction of erythroid differentiation by 5-azacytidine. Cell Differ 1984, 14(2):87-97

33)     Gambari R. Hexamethylenebisacetamide-mediated induction of murine erythroleukemia cells: relationship between expression of beta major and beta minor globin genes, globin mRNA synthesis and commitment to erythroid differentiation. Biochem Int 1983, 7(4):471-80

34)     Gambari R, Amelotti F, Barbieri R, Bernardi F, del Senno L. Epsilon-globin gene is undermethylated in K-562 cells: increased expression after treatment of the cells with 5-azacytidine. Cell Biol Int Rep 1984, 8(5):352

35)     Gambari R. Desferrioxamine-mediated inhibition of heme and hemoglobin synthesis in murine erythroleukemia cells: expression of globin genes and commitment to erythroid differentiation. Cell Biol Int Rep 1983, 7(10):785-95

36)     Gambari R, Raschella G, Tripodi M, Farace MG, Fantoni A. Desferrioxamine inhibits induced erythroid differentiation of human leukemic K-562 cells. Cell Differ 1983, 12(5):249-55

37)     Gambari R, Raschella G, Biagini R, Tripodi M, Farace MG, Romeo A, Fantoni A. Predominant expression of zeta and epsilon globin genes in human leukemia K-562(S6) variant cell line. Experientia 1983, 39(4):415-6

38)     Gambari R. Differential effect of dexamethasone on Friend leukemia cells induced to differentiate by hexamethylenebisacetamide or butyric acid. Cell Biol Int Rep 1982, 6(4):341

39)     Vanin EF, Farace MG, Gambari R, Fantoni A. The nucleotide sequence of the mouse embryonic beta-like y-globin messenger RNA as determined from cloned cDNA. Gene 1981, 16(1-3):141-8

40)     Fantoni A, Farace MG, Gambari R. Embryonic hemoglobins in man and other mammals. Blood 1981, 57(4):623-33

41)     Gambari R, Marks PA, Rifkind RA, Farace M, Fantoni A. Expression of erythroid differentiation and terminal cell division in induced Friend leukemia cells. Acta Biol Med Ger 1981, 40(4-5):511-8

42)     Fantoni A, Gambari R, Tripodi M, Raschella G, Morabito M, Farace MG. Control of globin gene expression in mouse yolk sac erythroid cells. Acta Biol Med Ger 1981, 40(4-5):499-503

43)     Gambari R, Fibach E, Rifkind RA, Marks PA. Inhibition of induced murine erythroleukemia cell differentiation by tumor promoters: relation to the cell cycle. Biochem Biophys Res Commun 1980, 94(3):867-74

44)     Gambari R, Rifkind RA, Marks PA. Stability of alpha and beta globin messenger RNA during induced differentiation of mouse erythroleukemia cells. Blood 1979, 54(4):933-9

45)     Gambari R, Marks PA, Rifkind RA. Murine erythroleukemia cell differentiation: relationship of globin gene expression and of prolongation of G1 to inducer effects during G1/early S. Proc Natl Acad Sci U S A 1979, 76(9):4511-5

46)     Marks PA, Rifkind RA, Bank A, Terada M, Gambari R, Fibach E, Maniatis G, Reuben R. Expression of globin genes during induced erythroleukemia cell differentiation . Cellular and molecular regulation of hemoglobin switching 1979, pp.413-421

47)     Rifkind RA, Fibach E, Maniatis G, Gambari R, Marks PA. Commitment to differentiation of normal and transformed erythroid precursors. Cellular and molecular regulation of hemoglobin switching 1979, pp. 421-36

48)     Fibach E, Gambari R, Shaw PA, Maniatis G, Reuben RC, Sassa S, Rifkind RA, Marks PA. Tumor promoter-mediated inhibition of cell differentiation: suppression of the expression of erythroid functions in murine erythroleukemia cells. Proc Natl Acad Sci U S A 1979, 76(4):1906-10

49)     Rossi GB, Aducci P, Gambari R, Minetti M, Vernole P. Presence of spectrin in untreated Friend erythroleukemic cells. Its accumulation upon treatment of the cells with dimethyl sulfoxide. J Cell Physiol 1978, 97:293-304

50)     Gambari R, Terada M, Bank A, Rifkind RA, Marks PA. Synthesis of globin mRNA in relation to the cell cycle during induced murine erythroleukemia differentiation. Proc Natl Acad Sci U S A 1978, 75(8):3801-4

51)     Ullu E, Gambari R, Farace MG, Lunadei M, Fantoni A. Isolation and characterization of the messenger RNAs for mouse embryonic globin chains. Eur J Biochem 1978, 88(1):315-22

52)     Ullu E, Farace MG, Gambari R, Orsi P, Lunadei M, Fantoni A. Terminal stages of erythroid differentiation: persistent production of globin messenger RNA is necessary to sustain globin synthesis. Blood 1978, 52(1):171-80

53)     Fantoni A, Ullu E, Gambari R, Lunadei M, Farace MG. Mouse foetal development: translational inactivation of globin genes during the terminal differentiation of yolk sac erythroid cells. Ann Immunol (Paris) 1976, 127(6):881-6

54)     Gambari R. Commitment to erythroid differentiation and globin gene expression in the absence of heme accumulation in Friend leukemia cells. Boll Soc Ital Biol Sper 1983 May 30;59(5):631-7